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Latest PhysioForum PostsKey protien in energy regulation identifiedMonday 08 March 2010 - 13:05:24 | International Physiotherapy News A key protein known as SIRT3 has been identified in energy regulation process. In a research by scientists at the Gladstone Institute of Virology and Immunology the authors concluded that acetylation is a new mechanism for regulating fatty acid oxidation in mitochondria and that SIRT3 mediates the acetylation state. Many mitochondrial proteins undergo a small chemical modification known as acetylation, which varies during feeding and fasting conditions. And it was known that the enzyme SIRT3 is involved in removing these modifications. The scientists used mice to investigate the role of the enzyme. Both the copies of the gene had been deleted in the mice. It was seen that mice that lost both copies of the SIRT3 gene appeared to be completely normal in normal food conditions but while the mice was tested under fasting conditions expression of SIRT3 was increased in the liver. The livers of mice without SIRT3 had higher levels of fat and triglycerides than normal mice, because the mice could not burn up the body fat. Looking further into the mitochondrial level, they found that the enzyme called LCAD was hyper acetylated and contained even more acetyl groups than usual and the enzyme had reduced activity. Analysis showed that higher levels of SIRT3 expression and activity increase the activity of LCAD enzyme in fat oxidation. A number of other proteins are also acetylated in the mitochondria, which suggests that other proteins may be involved. The authors were excited in saying "The implication is that SIRT3 may have a pathologic role in some metabolic disorders, such as diabetes, cardiovascular disease, or fatty liver disease. We are excited about exploring these possibilities." Source-ANI Mean age of stroke incidence coming down.Saturday 27 February 2010 - 18:03:44 | International Physiotherapy News A scary, shocking and very concerning data was revealed when researchers complied their datas on stroke incidence in the US. They found that the average age of stroke patients in 2005 was nearly three years younger than the average age of stroke patients in 1993-1994. They also noticed that the percentage of people 20 - 45 having a stroke was up to 7.3 percent in 2005 from 4.5 percent in 1993-1994. The proportion of patients under age 45 is up and the incidence rate is up too. The findings were presented at the American Stroke Association's International Stroke conference 2010 by the lead author Brett M. Kissela, Associate Professor, Co-Director of the Neurology Residency Program at the University of Cinccinatti Neuroscience Institute. Old News
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